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Citation
Royet, J., Bouwmeester, T., Cohen, S.M. (1998). Notchless encodes a novel WD40-repeat-containing protein that modulates notch signaling activity.  EMBO J. 17(24): 7351--7360.
FlyBase ID
FBrf0105918
Publication Type
Research paper
Abstract

Signaling by Notch family receptors is involved in many cell-fate decisions during development. Several modifiers of Notch activity have been identified, suggesting that regulation of Notch signaling is complex. In a genetic screen for modifiers of Notch activity, we identified a gene encoding a novel WD40-repeat protein. The gene is called Notchless, because loss-of-function mutant alleles dominantly suppress the wing notching caused by certain Notch alleles. Reducing Notchless activity increases Notch activity. Overexpression of Notchless in Xenopus or Drosophila appears to have a dominant-negative effect in that it also increases Notch activity. Biochemical studies show that Notchless binds to the cytoplasmic domain of Notch, suggesting that it serves as a direct regulator of Notch signaling activity.

PubMed ID
PubMed Central ID
PMC1171080 (PMC) (EuropePMC)
Associated Information
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    EMBO J.
    Title
    The EMBO Journal
    Publication Year
    1982-
    ISBN/ISSN
    0261-4189
    Data From Reference
    Aberrations (4)
    Alleles (18)
    Gene Groups (2)
    Genes (13)
    Insertions (1)
    Experimental Tools (1)
    Transgenic Constructs (3)