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Citation
Van Doren, M., Broihier, H.T., Moore, L.A., Lehmann, R. (1998). HMG-CoA reductase guides migrating primordial germ cells.  Nature 396(6710): 466--469.
FlyBase ID
FBrf0105951
Publication Type
Research paper
Abstract

The enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase is best known for catalysing a rate-limiting step in cholesterol biosynthesis, but it also participates in the production of a wide variety of other compounds. Some clinical benefits attributed to inhibitors of HMG-CoA reductase are now thought to be independent of any serum cholesterol-lowering effect. Here we describe a new cholesterol-independent role for HMG-CoA reductase, in regulating a developmental process: primordial germ cell migration. We show that in Drosophila this enzyme is highly expressed in the somatic gonad and that it is necessary for primordial germ cells to migrate to this tissue. Misexpression of HMG-CoA reductase is sufficient to attract primordial germ cells to tissues other than the gonadal mesoderm. We conclude that the regulated expression of HMG-CoA reductase has a critical developmental function in providing spatial information to guide migrating primordial germ cells.

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PubMed Central ID
Related Publication(s)
Review

Paper alert.
Jones, 1999, Curr. Opin. Genet. Dev. 9(1): 5 [FBrf0106722]

Note

Developmental biology. Attractive genetics.
Howard, 1998, Nature 396(6710): 406--407 [FBrf0105847]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nature
    Title
    Nature
    Publication Year
    1869-
    ISBN/ISSN
    0028-0836
    Data From Reference
    Alleles (9)
    Genes (6)
    Insertions (4)
    Experimental Tools (1)
    Transgenic Constructs (2)