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Citation
Apidianakis, Y., Nagel, A.C., Chalkiadaki, A., Preiss, A., Delidakis, C. (1999). Overexpression of the m4 and malpha genes of the E(spl)-complex antagonizes notch mediated lateral inhibition.  Mech. Dev. 86(1,2): 39--50.
FlyBase ID
FBrf0111325
Publication Type
Research paper
Abstract

Intercellular signalling mediated by Notch proteins is crucial to many cell fate decisions in metazoans. Its profound effects on cell fate and proliferation require that a complex set of responses involving positive and negative signal transducers be orchestrated around each instance of signalling. In Drosophila the basic-helix-loop-helix (bHLH) repressor encoding genes of the E(spl) locus are induced by Notch signalling and mediate some of its effects, such as suppression of neural fate. Here we report on a novel family of Notch responsive genes, whose products appear to act as antagonists of the Notch signal in the process of adult sensory organ precursor singularization. They, too, reside in the E(spl) locus and comprise transcription units E(spl) m4 and E(spl) malpha. Overexpression of these genes causes downregulation of E(spl) bHLH expression accompanied by cell autonomous overcommitment of sensory organ precursors and tufting of bristles. Interestingly, negative regulation of the Notch pathway by overexpression of E(spl) m4 and malpha is specific to the process of sensory organ precursor singularization and does not impinge on other instances of Notch signalling.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Mech. Dev.
    Title
    Mechanisms of Development
    Publication Year
    1990-
    ISBN/ISSN
    0925-4773
    Data From Reference
    Aberrations (5)
    Alleles (37)
    Gene Groups (1)
    Genes (27)
    Natural transposons (1)
    Insertions (9)
    Experimental Tools (2)
    Transgenic Constructs (15)
    Transcripts (4)