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Citation
Waddell, S., Armstrong, J.D., Kitamoto, T., Kaiser, K., Quinn, W.G. (2000). The amnesiac gene product is expressed in two neurons in the Drosophila brain that are critical for memory.  Cell 103(5): 805--813.
FlyBase ID
FBrf0132261
Publication Type
Research paper
Abstract

Mutations in the amnesiac gene in Drosophila affect both memory retention and ethanol sensitivity. The predicted amnesiac gene product, AMN, is an apparent preproneuropeptide, and previous studies suggest that it stimulates cAMP synthesis. Here we show that, unlike other learning-related Drosophila proteins, AMN is not preferentially expressed in mushroom bodies. Instead, it is strongly expressed in two large neurons that project over all the lobes of the mushroom bodies, a finding that suggests a modulatory role for AMN in memory formation. Genetically engineered blockade of vesicle recycling in these cells abbreviates memory as in the amnesiac mutant. Moreover, restoration of amn gene expression to these cells reestablishes normal olfactory memory in an amn deletion background. These results indicate that AMN neuropeptide release onto the mushroom bodies is critical for normal olfactory memory.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference
    Alleles (13)
    Genes (5)
    Insertions (7)
    Experimental Tools (1)
    Transgenic Constructs (2)
    Transcripts (6)