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Citation
Simpson, J.H., Kidd, T., Bland, K.S., Goodman, C.S. (2000). Short-range and long-range guidance by Slit and its Robo receptors: robo and Robo2 play distinct roles in midline guidance.  Neuron 28(3): 753--766.
FlyBase ID
FBrf0132431
Publication Type
Research paper
Abstract

Previous studies showed that Roundabout (Robo) in Drosophila is a repulsive axon guidance receptor that binds to Slit, a repellent secreted by midline glia. In robo mutants, growth cones cross and recross the midline, while, in slit mutants, growth cones enter the midline but fail to leave it. This difference suggests that Slit must have more than one receptor controlling midline guidance. In the absence of Robo, some other Slit receptor ensures that growth cones do not stay at the midline, even though they cross and recross it. Here we show that the Drosophila genome encodes three Robo receptors and that Robo and Robo2 have distinct functions, which together control repulsive axon guidance at the midline. The robo,robo2 double mutant is largely identical to slit.

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Note

New roundabouts send axons into the fas lane.
Rusch and Van Vactor, 2000, Neuron 28(3): 637--640 [FBrf0132429]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neuron
    Title
    Neuron
    Publication Year
    1988-
    ISBN/ISSN
    0896-6273
    Data From Reference