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Citation
Strutt, D.I. (2001). Asymmetric localization of frizzled and the establishment of cell polarity in the Drosophila wing.  Mol. Cell 7(2): 367--375.
FlyBase ID
FBrf0134764
Publication Type
Research paper
Abstract

The frizzled gene of Drosophila encodes a transmembrane receptor molecule required for cell polarity decisions in the adult cuticle. In the wing, a single trichome is produced by each cell, which normally points distally. In the absence of frizzled function, the trichomes no longer point uniformly distalward. We report that during cell polarization, the Frizzled receptor is localized to the distal cell edge, probably resulting in asymmetric Frizzled activity across the axis of the cell. Furthermore, Frizzled localization correlates with subsequent trichome polarity, suggesting that it may be an instructive cue in the determination of cell polarity. This differential receptor distribution may represent a novel mechanism for amplifying small differences in signaling activity across the axis of a cell.

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Personal communication to FlyBase

Arm-Fz-GFP and Act5C-FRT-Stop-FRT-Fz-EYFP constructs.
Strutt, 2003.10.8, Arm-Fz-GFP and Act5C-FRT-Stop-FRT-Fz-EYFP constructs. [FBrf0173063]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Mol. Cell
    Title
    Molecular Cell
    Publication Year
    1997-
    ISBN/ISSN
    1097-2765 1097-4164
    Data From Reference