Open Close
Reference
Citation
Kramer, S.G., Kidd, T., Simpson, J.H., Goodman, C.S. (2001). Switching repulsion to attraction: changing responses to slit during transition in mesoderm migration.  Science 292(5517): 737--740.
FlyBase ID
FBrf0135949
Publication Type
Research paper
Abstract

Slit is secreted by cells at the midline of the central nervous system, where it binds to Roundabout (Robo) receptors and functions as a potent repellent. We found that migrating mesodermal cells in vivo respond to Slit as both an attractant and a repellent and that Robo receptors are required for both functions. Mesoderm cells expressing Robo receptors initially migrate away from Slit at the midline. A few hours after migration, these same cells change their behavior and require Robo to extend toward Slit-expressing muscle attachment sites. Thus, Slit functions as a chemoattractant to provide specificity for muscle patterning.

PubMed ID
PubMed Central ID
Related Publication(s)
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Science
    Title
    Science
    Publication Year
    1895-
    ISBN/ISSN
    0036-8075 1095-9203
    Data From Reference
    Alleles (9)
    Genes (7)
    Insertions (3)
    Transgenic Constructs (3)