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Citation
Held, L.I. (2002). Bristles induce bracts via the EGFR pathway on Drosophila legs.  Mech. Dev. 117(1-2): 225--234.
FlyBase ID
FBrf0152194
Publication Type
Research paper
Abstract

A long-standing mystery in Drosophila has been: how do certain bristles induce adjacent cells to make bracts (a type of thick hair) on their proximal side? The apparent answer, based on loss- and gain-of-function studies, is that they emit a signal that neighbors then transduce via the epidermal growth factor receptor pathway. Suppressing this pathway removes bracts, while hyperactivating it evokes bracts indiscriminately on distal leg segments. Misexpression of the diffusible ligand Spitz (but not its membrane-bound precursor) elicits extra bracts at normal sites. What remains unclear is how a secreted signal can have effects in one specific direction.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Mech. Dev.
    Title
    Mechanisms of Development
    Publication Year
    1990-
    ISBN/ISSN
    0925-4773
    Data From Reference