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Citation
zur Lage, P.I., Prentice, D.R.A., Holohan, E.E., Jarman, A.P. (2003). The Drosophila proneural gene amos promotes olfactory sensillum formation and suppresses bristle formation.  Development 130(19): 4683--4693.
FlyBase ID
FBrf0162077
Publication Type
Research paper
Abstract

Proneural genes encode basic-helix-loop-helix (bHLH) transcription factors required for neural precursor specification. Recently amos was identified as a new candidate Drosophila proneural gene related to atonal. Having isolated the first specific amos loss-of-function mutations, we show definitively that amos is required to specify the precursors of two classes of olfactory sensilla. Unlike other known proneural mutations, a novel characteristic of amos loss of function is the appearance of ectopic sensory bristles in addition to loss of olfactory sensilla, owing to the inappropriate function of scute. This supports a model of inhibitory interactions between proneural genes, whereby ato-like genes (amos and ato) must suppress sensory bristle fate as well as promote alternative sense organ subtypes.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Development
    Title
    Development
    Publication Year
    1987-
    ISBN/ISSN
    0950-1991
    Data From Reference
    Aberrations (1)
    Alleles (12)
    Genes (10)
    Insertions (1)
    Experimental Tools (1)
    Transgenic Constructs (4)
    Transcripts (1)