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Citation
Sun, Y., Kanekar, S.L., Vetter, M.L., Gorski, S., Jan, Y.N., Glaser, T., Brown, N.L. (2003). Conserved and divergent functions of Drosophila atonal, amphibian, and mammalian Ath5 genes.  Evol. Dev. 5(5): 532--541.
FlyBase ID
FBrf0162106
Publication Type
Research paper
Abstract

Insect and vertebrate eyes differ in their formation, cellular composition, neural connectivity, and visual function. Despite this diversity, Drosophila atona and its vertebrate Ortholog in the eye, Ath5, each regulate determination of the first retinal neuron class-R8 photo-receptors and retinal ganglion cells (RGCs)-in their respective organisms. We have performed a cross-species functional comparison of these genes. In ato mutant Drosophila, ectopic Xenopus Ath5 (Xath5) rescues photoreceptor cell development comparably with atonaI. In contrast, mouse Ath5 (Math5) induces formation of very few ommatidia, and most of these lack R8 cells. In the developing frog eye, ectopic atonal, like Xath5, promotes the differentiation RGCs. Despite strong conservation of atonaI, Xath5, and Math5 structure and shared function, other factors must contribute to the species specificity of retinal neuron determination. These observations suggest that the atonaI family may occupy a position in a gene hierarchy where differences in gene regulation or function can be correlated with evolutionary diversity of eye development.

PubMed ID
PubMed Central ID
PMC2262842 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Evol. Dev.
    Title
    Evolution and Development
    Publication Year
    1-
    ISBN/ISSN
    1520-541X
    Data From Reference
    Alleles (7)
    Genes (10)
    Natural transposons (1)
    Insertions (1)
    Experimental Tools (1)
    Transgenic Constructs (5)