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Citation
Loewer, A., Soba, P., Beyreuther, K., Paro, R., Merdes, G. (2004). Cell-type-specific processing of the amyloid precursor protein by Presenilin during Drosophila development.  EMBO Rep. 5(4): 405--411.
FlyBase ID
FBrf0174609
Publication Type
Research paper
Abstract

The cleavage of proteins within their transmembrane domain by Presenilin (PS) has an important role in different signalling pathways and in Alzheimer's disease. Nevertheless, not much is known about the regulation of PS activity. It has been suggested that substrate recognition by the PS complex depends only on the size of the extracellular domain independent of the amino-acid sequence and that PS activity is constitutive in all cells that express the minimal components of the complex. We report here the development of an in vivo reporter system that allowed us to analyse the processing of human amyloid precursor protein (APP) and the Notch receptor tissue specifically during Drosophila development in the living organism. Using this system, we demonstrate differences between APP and Notch processing and show that PS-mediated cleavage of APP can be regulated in different cell types independent of the size of the extracellular domain.

PubMed ID
PubMed Central ID
PMC1299033 (PMC) (EuropePMC)
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Supplementary material

Supplementary Data. [FBrf0210003]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    EMBO Rep.
    Title
    EMBO Reports
    Publication Year
    2000-
    ISBN/ISSN
    1469-221X 1469-3178
    Data From Reference