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Moschetti, R., Marsano, R.M., Barsanti, P., Caggese, C., Caizzi, R. (2004). FB elements can promote exon shuffling: a promoter-less white allele can be reactivated by FB mediated transposition in Drosophila melanogaster.  Mol. Genet. Genomics 271(): 394--401.
FlyBase ID
FBrf0186074
Publication Type
Research paper
Abstract

Foldback ( FB) elements are transposable elements found in many eukaryotic genomes; they are thought to contribute significantly to genome plasticity. In Drosophila melanogaster, FBs have been shown to be involved in the transposition of large chromosomal regions and in the genetic instability of some alleles of the white gene. In this report we show that FB mediated transposition of w(67C23), a mutation that deletes the promoter of the white gene and its first exon, containing the start codon, can restore expression of the white gene. We have characterized three independent events in which a 14-kb fragment from the w(67C23) locus was transposed into an intron region in three different genes. In each case a local promoter drives the expression of white, producing a chimeric mRNA. These findings suggest that, on an evolutionary timescale, FB elements may contribute to the creation of new genes via exon shuffling.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Mol. Genet. Genomics
    Title
    Molecular Genetics and Genomics
    Publication Year
    2001-
    ISBN/ISSN
    1617-4615 1617-4623
    Data From Reference
    Aberrations (6)
    Alleles (10)
    Genes (4)
    Natural transposons (3)