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Citation
Fishilevich, E., Vosshall, L.B. (2005). Genetic and functional subdivision of the Drosophila antennal lobe.  Curr. Biol. 15(17): 1548--1553.
FlyBase ID
FBrf0187306
Publication Type
Research paper
Abstract

Olfactory systems confer the recognition and discrimination of a large number of structurally distinct odor molecules. Recent molecular analysis of odorant receptor (OR) genes and circuits has led to a model of odor coding in which a population of olfactory sensory neurons (OSNs) expressing a single OR converges upon a unique olfactory glomerulus. Activation of the OR can thus be read out by the activation of its cognate glomerulus. Drosophila is a powerful system in which to test this model because the entire repertoire of 62 ORs can be manipulated genetically. However, a complete understanding of how fly olfactory circuits are organized is lacking. Here, we present a nearly complete map of OR projections from OSNs to the antennal lobe (AL) in the fly brain. Four populations of OSNs coexpress two ORs along with Or83b, and a fifth expresses one OR and one gustatory receptor (GR) along with Or83b. One glomerulus receives coconvergent input from two separate populations of OSNs. Three ORs label sexually dimorphic glomeruli implicated in sexual courtship and are thus candidate Drosophila pheromone receptors. This olfactory sensory map provides an experimental framework for relating ORs to glomeruli and ultimately behavior.

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Related Publication(s)
Review

Insect olfaction: a map of smell in the brain.
Jefferis, 2005, Curr. Biol. 15(17): R668--R670 [FBrf0190021]

Erratum

Genetic and functional subdivision of the Drosophila antennal lobe (vol 15, pg 1548, 2005).
Fishilevich and Vosshall, 2007, Curr. Biol. 17(13): 1180 [FBrf0201681]

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Curr. Biol.
    Title
    Current Biology
    Publication Year
    1991-
    ISBN/ISSN
    0960-9822
    Data From Reference
    Alleles (40)
    Genes (44)
    Sequence Features (23)
    Natural transposons (1)
    Experimental Tools (1)
    Transgenic Constructs (40)
    Transcripts (28)