Open Close
Reference
Citation
Ishimoto, H., Takahashi, K., Ueda, R., Tanimura, T. (2005). G-protein gamma subunit 1 is required for sugar reception in Drosophila.  EMBO J. 24(18): 3259--3265.
FlyBase ID
FBrf0187509
Publication Type
Research paper
Abstract

Though G-proteins have been implicated in the primary step of taste signal transduction, no direct demonstration has been done in insects. We show here that a G-protein gamma subunit, Ggamma1, is required for the signal transduction of sugar taste reception in Drosophila. The Ggamma1 gene is expressed mainly in one of the gustatory receptor neurons. Behavioral responses of the flies to sucrose were reduced by the targeted suppression of neural functions of Ggamma1-expressing cells using neural modulator genes such as the modified Shaker K+ channel (EKO), the tetanus toxin light chain or the shibire (shi(ts1)) gene. RNA interference targeting to the Ggamma1 gene reduced the amount of Ggamma1 mRNA and suppressed electrophysiological response of the sugar receptor neuron. We also demonstrated that responses to sugars were lowered in Ggamma1 null mutant, Ggamma1(N159). These results are consistent with the hypothesis that Ggamma1 participates in the signal transduction of sugar taste reception.

PubMed ID
PubMed Central ID
PMC1224686 (PMC) (EuropePMC)
Related Publication(s)
Erratum

Erratum to "G-protein gamma subunit 1 is required for sugar reception in Drosophila" (vol 24, pg 3259, 2005).
Ishimoto et al., 2005, EMBO J. 24(19): 3516 [FBrf0190360]

Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    EMBO J.
    Title
    The EMBO Journal
    Publication Year
    1982-
    ISBN/ISSN
    0261-4189
    Data From Reference
    Alleles (10)
    Genes (7)
    Natural transposons (1)
    Insertions (4)
    Experimental Tools (1)
    Transgenic Constructs (5)