Open Close
Reference
Citation
Kocks, C., Cho, J.H., Nehme, N., Ulvila, J., Pearson, A.M., Meister, M., Strom, C., Conto, S.L., Hetru, C., Stuart, L.M., Stehle, T., Hoffmann, J.A., Reichhart, J.M., Ferrandon, D., Rämet, M., Ezekowitz, R.A. (2005). Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila.  Cell 123(2): 335--346.
FlyBase ID
FBrf0189912
Publication Type
Research paper
Abstract

Phagocytosis is a complex, evolutionarily conserved process that plays a central role in host defense against infection. We have identified a predicted transmembrane protein, Eater, which is involved in phagocytosis in Drosophila. Transcriptional silencing of the eater gene in a macrophage cell line led to a significant reduction in the binding and internalization of bacteria. Moreover, the N terminus of the Eater protein mediated direct microbial binding which could be inhibited with scavenger receptor ligands, acetylated, and oxidized low-density lipoprotein. In vivo, eater expression was restricted to blood cells. Flies lacking the eater gene displayed normal responses in NF-kappaB-like Toll and IMD signaling pathways but showed impaired phagocytosis and decreased survival after bacterial infection. Our results suggest that Eater is a major phagocytic receptor for a broad range of bacterial pathogens in Drosophila and provide a powerful model to address the role of phagocytosis in vivo.

PubMed ID
PubMed Central ID
Related Publication(s)
Note

Eater: a big bite into phagocytosis.
Erturk-Hasdemir and Silverman, 2005, Cell 123(2): 190--192 [FBrf0189908]

Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference
    Aberrations (2)
    Alleles (4)
    Genes (11)
    Human Disease Models (3)
    Natural transposons (1)
    Insertions (2)
    Experimental Tools (1)
    Transgenic Constructs (4)