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Citation
Yui, R., Matsuura, E.T. (2006). Detection of deletions flanked by short direct repeats in mitochondrial DNA of aging Drosophila.  Mutat. Res. 594(1-2): 155--161.
FlyBase ID
FBrf0192775
Publication Type
Research paper
Abstract

Cumulative damage due to reactive oxygen species (ROS) in mitochondria, especially in mitochondrial DNA (mtDNA), would result in a decrease in mitochondrial respiratory function and contributes to the age-related decline in the physiological functioning of organisms. Previously, we reported the tissue-specific accumulation of deleted mtDNA with age in Drosophila melanogaster. In the present study, to understand the mechanism by which mtDNA deletion is generated with age, nucleotide sequences of deleted mtDNA were determined. Consequently, 33 different sequences each containing a deletion were obtained from flies that were more than 55-day-old. Most of the deletions were found to be flanked by short direct repeats. The present results, together with those from other animals, suggest that there is a common mechanism generating mtDNA deletions through direct repeats.

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PubMed Central ID
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Secondary IDs
  • FBrf0191226
Language of Publication
English
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Parent Publication
Publication Type
Journal
Abbreviation
Mutat. Res.
Title
Mutation Research
Publication Year
1964-
ISBN/ISSN
0027-5107
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