FB2025_01 , released February 20, 2025
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Citation
Quaiser, (2006). Kinases and G proteins join the Wnt receptor complex.  BioEssays 28(4): 339--343.
FlyBase ID
FBrf0198749
Publication Type
Review
Abstract
Wnt proteins form a family of secreted signaling proteins that play a key role in various developmental events such as cell differentiation, cell migration, cell polarity and cell proliferation. It is currently thought that Wnt proteins activate at least three different signaling pathways by binding to seven transmembrane receptors of the Frizzled family and the co-receptor LRP6. Despite our growing knowledge of intracellular components that mediate a Wnt signal, the molecular events at the membrane have remained rather unclear. Now several publications(1-4) indicate that Frizzled receptors are G-protein coupled and kinases were identified that phosphorylate the co-receptor LRP6. These data deepen our understanding of Wnt-mediated signal transduction and provide more insight into how specificity may be achieved.
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    BioEssays
    Title
    BioEssays
    Publication Year
    1984-
    ISBN/ISSN
    0265-9247
    Data From Reference
    Genes (8)