FB2025_01 , released February 20, 2025
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Citation
Lawrence, P.A., Struhl, G., Casal, J. (2007). Planar cell polarity: one or two pathways?  Nat. Rev. Genet. 8(7): 555--563.
FlyBase ID
FBrf0202004
Publication Type
Review
Abstract
In multicellular organisms, cells are polarized in the plane of the epithelial sheet, revealed in some cell types by oriented hairs or cilia. Many of the underlying genes have been identified in Drosophila melanogaster and are conserved in vertebrates. Here we dissect the logic of planar cell polarity (PCP). We review studies of genetic mosaics in adult flies - marked cells of different genotypes help us to understand how polarizing information is generated and how it passes from one cell to another. We argue that the prevailing opinion that planar polarity depends on a single genetic pathway is wrong and conclude that there are (at least) two independently acting processes. This conclusion has major consequences for the PCP field.
PubMed ID
PubMed Central ID
PMC2747024 (PMC) (EuropePMC)
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