Open Close
Reference
Citation
Park, E., Suh, H., Kim, C., Park, S., Dorsett, D., Yim, J. (2007). Son of Notch, a winged-helix gene involved in boundary formation in the Drosophila wing.  IUBMB Life 59(12): 781--790.
FlyBase ID
FBrf0202263
Publication Type
Research paper
Abstract

A P element enhancer trap screen was conducted to identify genes involved in dorsal-ventral boundary formation in Drosophila. The son of Notch (son) gene was identified by the son(2205) enhancer trap insertion, which is a partial loss-of-function mutation. Based on son(2205) mutant phenotypes and genetic interactions with Notch and wingless mutations, we conclude that son participates in wing development, and functions in the Notch signaling pathway at the dorsal-ventral boundary in the wing. Notch signaling pathway components activate son enhancer trap expression in wing cells. son enhancer trap expression is regulated positively by wingless, and negatively by cut in boundary cells. Ectopic Son protein induces wingless and cut expression in wing discs. We hypothesize that there is positive feedback regulation of son by wingless, and negative regulation by cut at the dorsal-ventral boundary during wing development.

PubMed ID
PubMed Central ID
PMC2258214 (PMC) (EuropePMC)
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    IUBMB Life
    Title
    IUBMB Life
    Publication Year
    1999-
    ISBN/ISSN
    1521-6543 1521-6551
    Data From Reference
    Alleles (16)
    Genes (10)
    Physical Interactions (1)
    Natural transposons (1)
    Insertions (3)
    Experimental Tools (3)
    Transgenic Constructs (9)
    Transcripts (2)