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Citation
Diop, S.B., Bertaux, K., Vasanthi, D., Sarkeshik, A., Goirand, B., Aragnol, D., Tolwinski, N.S., Cole, M.D., Pradel, J., Yates, J.R., Mishra, R.K., Graba, Y., Saurin, A.J. (2008). Reptin and Pontin function antagonistically with PcG and TrxG complexes to mediate Hox gene control.  EMBO Rep. 9(3): 260--266.
FlyBase ID
FBrf0204282
Publication Type
Research paper
Abstract

Pontin (Pont) and Reptin (Rept) are paralogous ATPases that are evolutionarily conserved from yeast to human. They are recruited in multiprotein complexes that function in various aspects of DNA metabolism. They are essential for viability and have antagonistic roles in tissue growth, cell signalling and regulation of the tumour metastasis suppressor gene, KAI1, indicating that the balance of Pont and Rept regulates epigenetic programmes critical for development and cancer progression. Here, we describe Pont and Rept as antagonistic mediators of Drosophila Hox gene transcription, functioning with Polycomb group (PcG) and Trithorax group proteins to maintain correct patterns of expression. We show that Rept is a component of the PRC1 PcG complex, whereas Pont purifies with the Brahma complex. Furthermore, the enzymatic functions of Rept and Pont are indispensable for maintaining Hox gene expression states, highlighting the importance of these two antagonistic factors in transcriptional output.

PubMed ID
PubMed Central ID
PMC2267392 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    EMBO Rep.
    Title
    EMBO Reports
    Publication Year
    2000-
    ISBN/ISSN
    1469-221X 1469-3178
    Data From Reference
    Alleles (10)
    Gene Groups (1)
    Genes (15)
    Natural transposons (1)
    Experimental Tools (1)
    Transgenic Constructs (6)