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Deddouche, S., Matt, N., Budd, A., Mueller, S., Kemp, C., Galiana-Arnoux, D., Dostert, C., Antoniewski, C., Hoffmann, J.A., Imler, J.L. (2008). The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila.  Nat. Immunol. 9(12): 1425--1432.
FlyBase ID
FBrf0206193
Publication Type
Research paper
Abstract

Drosophila, like other invertebrates and plants, relies mainly on RNA interference for its defense against viruses. In flies, viral infection also triggers the expression of many genes. One of the genes induced, Vago, encodes a 18-kilodalton cysteine-rich polypeptide. Here we provide genetic evidence that the Vago gene product controlled viral load in the fat body after infection with drosophila C virus. Induction of Vago was dependent on the helicase Dicer-2. Dicer-2 belongs to the same DExD/H-box helicase family as do the RIG-I-like receptors, which sense viral infection and mediate interferon induction in mammals. We propose that this family represents an evolutionary conserved set of sensors that detect viral nucleic acids and direct antiviral responses.

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PubMed Central ID
Related Publication(s)
Note

RIG-I-like antiviral protein in flies.
Takeuchi and Akira, 2008, Nat. Immunol. 9(12): 1327--1328 [FBrf0215625]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Immunol.
    Title
    Nature Immunology
    Publication Year
    2000-
    ISBN/ISSN
    1529-2908 1529-2916
    Data From Reference
    Aberrations (1)
    Alleles (16)
    Genes (15)
    Natural transposons (1)
    Insertions (1)
    Experimental Tools (2)
    Transgenic Constructs (9)