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Citation
Gao, S., Takemura, S.Y., Ting, C.Y., Huang, S., Lu, Z., Luan, H., Rister, J., Thum, A.S., Yang, M., Hong, S.T., Wang, J.W., Odenwald, W.F., White, B.H., Meinertzhagen, I.A., Lee, C.H. (2008). The neural substrate of spectral preference in Drosophila.  Neuron 60(2): 328--342.
FlyBase ID
FBrf0206213
Publication Type
Research paper
Abstract

Drosophila vision is mediated by inputs from three types of photoreceptor neurons; R1-R6 mediate achromatic motion detection, while R7 and R8 constitute two chromatic channels. Neural circuits for processing chromatic information are not known. Here, we identified the first-order interneurons downstream of the chromatic channels. Serial EM revealed that small-field projection neurons Tm5 and Tm9 receive direct synaptic input from R7 and R8, respectively, and indirect input from R1-R6, qualifying them to function as color-opponent neurons. Wide-field Dm8 amacrine neurons receive input from 13-16 UV-sensing R7s and provide output to projection neurons. Using a combinatorial expression system to manipulate activity in different neuron subtypes, we determined that Dm8 neurons are necessary and sufficient for flies to exhibit phototaxis toward ultraviolet instead of green light. We propose that Dm8 sacrifices spatial resolution for sensitivity by relaying signals from multiple R7s to projection neurons, which then provide output to higher visual centers.

PubMed ID
PubMed Central ID
PMC2665173 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neuron
    Title
    Neuron
    Publication Year
    1988-
    ISBN/ISSN
    0896-6273
    Data From Reference