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Duch, C., Vonhoff, F., Ryglewski, S. (2008). Dendrite elongation and dendritic branching are affected separately by different forms of intrinsic motoneuron excitability.  J. Neurophysiol. 100(5): 2525--2536.
FlyBase ID
FBrf0207189
Publication Type
Research paper
Abstract

Dendrites are the fundamental determinant of neuronal wiring. Consequently dendritic defects are associated with numerous neurological diseases and mental retardation. Neuronal activity can have profound effects on dendritic structure, but the mechanisms controlling distinct aspects of dendritic architecture are not fully understood. We use the Drosophila genetic model system to test the effects of altered intrinsic excitability on postembryonic dendritic architecture development. Targeted dominant negative knock-downs of potassium channel subunits allow for selectively increasing the intrinsic excitability of a selected subset of motoneurons, whereas targeted expression of a genetically modified noninactivating potassium channel decrease intrinsic excitability in vivo. Both manipulations cause significant dendritic overgrowth, but by different mechanisms. Increased excitability causes increased dendritic branch formation, whereas decreased excitability causes increased dendritic branch elongation. Therefore dendritic branching and branch elongation are controlled by separate mechanisms that can be addressed selectively in vivo by different manipulations of neuronal intrinsic excitability.

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    Language of Publication
    English
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    Parent Publication
    Publication Type
    Journal
    Abbreviation
    J. Neurophysiol.
    Title
    Journal of Neurophysiology
    Publication Year
    1938-
    ISBN/ISSN
    0022-3077
    Data From Reference
    Alleles (5)
    Genes (4)
    Insertions (1)
    Transgenic Constructs (4)