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Citation
Donlea, J.M., Ramanan, N., Shaw, P.J. (2009). Use-dependent plasticity in clock neurons regulates sleep need in Drosophila.  Science 324(5923): 105--108.
FlyBase ID
FBrf0207700
Publication Type
Research paper
Abstract

Sleep is important for memory consolidation and is responsive to waking experience. Clock circuitry is uniquely positioned to coordinate interactions between processes underlying memory and sleep need. Flies increase sleep both after exposure to an enriched social environment and after protocols that induce long-term memory. We found that flies mutant for rutabaga, period, and blistered were deficient for experience-dependent increases in sleep. Rescue of each of these genes within the ventral lateral neurons (LNVs) restores increased sleep after social enrichment. Social experiences that induce increased sleep were associated with an increase in the number of synaptic terminals in the LNV projections into the medulla. The number of synaptic terminals was reduced during sleep and this decline was prevented by sleep deprivation.

PubMed ID
PubMed Central ID
PMC2850598 (PMC) (EuropePMC)
Related Publication(s)
Note

Neuroscience. Sleeping to reset overstimulated synapses.
Miller, 2009, Science 324(5923): 22 [FBrf0207740]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Science
    Title
    Science
    Publication Year
    1895-
    ISBN/ISSN
    0036-8075 1095-9203
    Data From Reference
    Aberrations (1)
    Alleles (48)
    Genes (10)
    Insertions (33)
    Transgenic Constructs (11)