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Citation
Shuai, Y., Lu, B., Hu, Y., Wang, L., Sun, K., Zhong, Y. (2010). Forgetting Is Regulated through Rac Activity in Drosophila.  Cell 140(4): 579--589.
FlyBase ID
FBrf0210130
Publication Type
Research paper
Abstract

Initially acquired memory dissipates rapidly if not consolidated. Such memory decay is thought to result either from the inherently labile nature of newly acquired memories or from interference by subsequently attained information. Here we report that a small G protein Rac-dependent forgetting mechanism contributes to both passive memory decay and interference-induced forgetting in Drosophila. Inhibition of Rac activity leads to slower decay of early memory, extending it from a few hours to more than one day, and to blockade of interference-induced forgetting. Conversely, elevated Rac activity in mushroom body neurons accelerates memory decay. This forgetting mechanism does not affect memory acquisition and is independent of Rutabaga adenylyl cyclase-mediated memory formation mechanisms. Endogenous Rac activation is evoked on different time scales during gradual memory loss in passive decay and during acute memory removal in reversal learning. We suggest that Rac's role in actin cytoskeleton remodeling may contribute to memory erasure.

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Obtained with permission from Cell Press.
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PubMed Central ID
Related Publication(s)
Note

Rac in the act of forgetting.
Davis, 2010, Cell 140(4): 456--458 [FBrf0214838]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference