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Citation
Wang, Y., Werz, C., Xu, D., Chen, Z., Li, Y., Hafen, E., Bergmann, A. (2008). Drosophila cbl is essential for control of cell death and cell differentiation during eye development.  PLoS ONE 3(1): e1447.
FlyBase ID
FBrf0210285
Publication Type
Research paper
Abstract

Activation of cell surface receptors transduces extracellular signals into cellular responses such as proliferation, differentiation and survival. However, as important as the activation of these receptors is their appropriate spatial and temporal down-regulation for normal development and tissue homeostasis. The Cbl family of E3-ubiquitin ligases plays a major role for the ligand-dependent inactivation of receptor tyrosine kinases (RTKs), most notably the Epidermal Growth Factor Receptor (EGFR) through ubiquitin-mediated endocytosis and lysosomal degradation.Here, we report the mutant phenotypes of Drosophila cbl (D-cbl) during eye development. D-cbl mutants display overgrowth, inhibition of apoptosis, differentiation defects and increased ommatidial spacing. Using genetic interaction and molecular markers, we show that most of these phenotypes are caused by increased activity of the Drosophila EGFR. Our genetic data also indicate a critical role of ubiquitination for D-cbl function, consistent with biochemical models.These data may provide a mechanistic model for the understanding of the oncogenic activity of mammalian cbl genes.

PubMed ID
PubMed Central ID
PMC2180199 (PMC) (EuropePMC)
Related Publication(s)
Personal communication to FlyBase

Correction of Cbl[L31] and Cbl[7] molecular characterization data.
Bergmann, 2013.10.22, Correction of Cbl[L31] and Cbl[7] molecular characterization data. [FBrf0223065]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    PLoS ONE
    Title
    PLoS ONE
    Publication Year
    2006-
    ISBN/ISSN
    1932-6203
    Data From Reference