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Citation
Metta, M., Schlötterer, C. (2010). Non-random genomic integration - an intrinsic property of retrogenes in Drosophila?  BMC Evol. Biol. 10(): 114.
FlyBase ID
FBrf0210914
Publication Type
Research paper
Abstract

The Drosophila X-chromosome shows a significant underrepresentation of genes with male-biased gene expression (demasculinization). This trend is matched by retrogenes, which typically have a male biased gene expression pattern and show a significant movement bias from X-chromosomes to autosomes. It is currently assumed that these patterns are best explained by selection, either mediated by male meiotic sex chromosome inactivation (MSCI) or sexually antagonistic forces. We scrutinized the evolutionary dynamics of retroposition by focusing on retrogenes for which the parental copy has degenerated.Consistent with a functional substitution of the degenerated gene by the retrogene, patterns of sequence evolution and gene expression were similar between retroposed and parental genes. Like previous studies, our set of retrogenes showed a significant movement off the X-chromosome. In contrast to data sets where retroposition caused gene duplication, the genes in our study showed primarily female-biased or unbiased gene expression.Based on our results, the biased transposition pattern cannot be explained by MSCI and probably not by sexual antagonism. Rather, we propose that the movement away from the X-chromosome represents a general property of retroposition in Drosophila.

PubMed ID
PubMed Central ID
PMC2879276 (PMC) (EuropePMC)
Related Publication(s)
FlyBase analysis

Summary of published retrogene analyses.
dos Santos, 2014, Summary of published retrogene analyses. [FBrf0225799]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    BMC Evol. Biol.
    Title
    BMC Evolutionary Biology
    Publication Year
    2001-
    ISBN/ISSN
    1471-2148
    Data From Reference