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Citation
Abreu-Blanco, M.T., Verboon, J.M., Parkhurst, S.M. (2011). Cell wound repair in Drosophila occurs through three distinct phases of membrane and cytoskeletal remodeling.  J. Cell Biol. 193(3): 455--464.
FlyBase ID
FBrf0213583
Publication Type
Research paper
Abstract

When single cells or tissues are injured, the wound must be repaired quickly in order to prevent cell death, loss of tissue integrity, and invasion by microorganisms. We describe Drosophila as a genetically tractable model to dissect the mechanisms of single-cell wound repair. By analyzing the expression and the effects of perturbations of actin, myosin, microtubules, E-cadherin, and the plasma membrane, we define three distinct phases in the repair process-expansion, contraction, and closure-and identify specific components required during each phase. Specifically, plasma membrane mobilization and assembly of a contractile actomyosin ring are required for this process. In addition, E-cadherin accumulates at the wound edge, and wound expansion is excessive in E-cadherin mutants, suggesting a role for E-cadherin in anchoring the actomyosin ring to the plasma membrane. Our results show that single-cell wound repair requires specific spatial and temporal cytoskeleton responses with distinct components and mechanisms required at different stages of the process.

PubMed ID
PubMed Central ID
PMC3087011 (PMC) (EuropePMC)
Related Publication(s)
Note

Single cell wound repair: Dealing with life's little traumas.
Abreu-Blanco et al., 2011, Bioarchitecture 1(3): 114--121 [FBrf0215583]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    J. Cell Biol.
    Title
    Journal of Cell Biology
    Publication Year
    1966-
    ISBN/ISSN
    0021-9525
    Data From Reference