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Citation
Gohl, D., Aoki, T., Blanton, J., Shanower, G., Kappes, G., Schedl, P. (2011). Mechanism of chromosomal boundary action: roadblock, sink, or loop?  Genetics 187(3): 731--748.
FlyBase ID
FBrf0214438
Publication Type
Research paper
Abstract

Boundary elements or insulators subdivide eukaryotic chromosomes into a series of structurally and functionally autonomous domains. They ensure that the action of enhancers and silencers is restricted to the domain in which these regulatory elements reside. Three models, the roadblock, sink/decoy, and topological loop, have been proposed to explain the insulating activity of boundary elements. Strong predictions about how boundaries will function in different experimental contexts can be drawn from these models. In the studies reported here, we have designed assays that test these predictions. The results of our assays are inconsistent with the expectations of the roadblock and sink models. Instead, they support the topological loop model.

PubMed ID
PubMed Central ID
PMC3063668 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genetics
    Title
    Genetics
    Publication Year
    1916-
    ISBN/ISSN
    0016-6731
    Data From Reference