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Zheng, L., Michelson, Y., Freger, V., Avraham, Z., Venken, K.J., Bellen, H.J., Justice, M.J., Wides, R. (2011). Drosophila Ten-m and Filamin Affect Motor Neuron Growth Cone Guidance.  PLoS ONE 6(8): e22956.
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Research paper

The Drosophila Ten-m (also called Tenascin-major, or odd Oz (odz)) gene has been associated with a pair-rule phenotype. We identified and characterized new alleles of Drosophila Ten-m to establish that this gene is not responsible for segmentation defects but rather causes defects in motor neuron axon routing. In Ten-m mutants the inter-segmental nerve (ISN) often crosses segment boundaries and fasciculates with the ISN in the adjacent segment. Ten-m is expressed in the central nervous system and epidermal stripes during the stages when the growth cones of the neurons that form the ISN navigate to their targets. Over-expression of Ten-m in epidermal cells also leads to ISN misrouting. We also found that Filamin, an actin binding protein, physically interacts with the Ten-m protein. Mutations in cheerio, which encodes Filamin, cause defects in motor neuron axon routing like those of Ten-m. During embryonic development, the expression of Filamin and Ten-m partially overlap in ectodermal cells. These results suggest that Ten-m and Filamin in epidermal cells might together influence growth cone progression.

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PMC3152545 (PMC) (EuropePMC)
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    PLoS ONE
    PLoS ONE
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    Aberrations (4)
    Alleles (19)
    Balancers (1)
    Genes (6)
    Physical Interactions (3)
    Polypeptides (1)
    Natural transposons (1)
    Insertions (7)
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    Transgenic Constructs (4)