FB2025_01 , released February 20, 2025
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Citation
Canela-Xandri, O., Sagués, F., Reigada, R., Buceta, J. (2008). A spatial toggle switch drives boundary formation in development.  Biophys. J. 95(11): 5111--5120.
FlyBase ID
FBrf0215715
Publication Type
Research paper
Abstract
Herein we introduce a multicellular network motif that performs as a spatial toggle switch and explains how boundary formation can be faithfully accomplished in developmental processes. Importantly, we show that expression and activity patterns of proteins must be simultaneously characterized for a proper understanding and description of the underlying mechanism. Our in silico experiments, in agreement with in vivo results, evaluate different genetic backgrounds and shed light on the dynamics of boundary formation. In addition, we provide an estimation of relevant biological parameters and a robustness analysis.
PubMed ID
PubMed Central ID
PMC2586583 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Biophys. J.
    Title
    Biophysical Journal
    Publication Year
    1960-
    ISBN/ISSN
    0006-3495
    Data From Reference
    Genes (4)