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Citation
Marygold, S.J., Walker, C.W., Orme, M.H., Leevers, S.J. (2011). Genetic characterization of ebi reveals its critical role in Drosophila wing growth.  Fly 5(4): 291--303.
FlyBase ID
FBrf0216882
Publication Type
Research paper
Abstract

The ebi gene of Drosophila melanogaster has been implicated in diverse signalling pathways, cellular functions and developmental processes. However, a thorough genetic analysis of this gene has been lacking and the true extent of its biological roles is unclear. Here, we characterize eleven ebi mutations and find that ebi has a novel role in promoting growth of the wing imaginal disc: viable combinations of mutant alleles give rise to adults with small wings. Wing discs with reduced EBI levels are correspondingly small and exhibit down-regulation of Notch target genes. Furthermore, we show that EBI colocalizes on polytene chromosomes with Smrter (SMR), a transcriptional corepressor, and Suppressor of Hairless (SU(H)), the primary transcription factor involved in Notch signalling. Interestingly, the mammalian orthologs of ebi, transducin β-like 1 (TBL1) and TBL-related 1 (TBLR1), function as corepressor/coactivator exchange factors and are required for transcriptional activation of Notch target genes. We hypothesize that EBI acts to activate (de-repress) transcription of Notch target genes important for Drosophila wing growth by functioning as a corepressor/coactivator exchange factor for SU(H).

PubMed ID
PubMed Central ID
PMC3266070 (PMC) (EuropePMC)
Related Publication(s)
Personal communication to FlyBase

Location data for ebi[Delta1] deletion mutation.
Marygold S.J., 2013.09.06, Location data for ebi[Delta1] deletion mutation. [FBrf0222650]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Fly
    Title
    Fly
    Publication Year
    2007-
    ISBN/ISSN
    1933-6934 1933-6942
    Data From Reference