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Citation
Shohat-Ophir, G., Kaun, K.R., Azanchi, R., Heberlein, U. (2012). Sexual deprivation increases ethanol intake in Drosophila.  Science 335(6074): 1351--1355.
FlyBase ID
FBrf0217810
Publication Type
Research paper
Abstract

The brain's reward systems reinforce behaviors required for species survival, including sex, food consumption, and social interaction. Drugs of abuse co-opt these neural pathways, which can lead to addiction. Here, we used Drosophila melanogaster to investigate the relationship between natural and drug rewards. In males, mating increased, whereas sexual deprivation reduced, neuropeptide F (NPF) levels. Activation or inhibition of the NPF system in turn reduced or enhanced ethanol preference. These results thus link sexual experience, NPF system activity, and ethanol consumption. Artificial activation of NPF neurons was in itself rewarding and precluded the ability of ethanol to act as a reward. We propose that activity of the NPF-NPF receptor axis represents the state of the fly reward system and modifies behavior accordingly.

PubMed ID
PubMed Central ID
PMC3909676 (PMC) (EuropePMC)
Related Publication(s)
Note

Physiology. She said no, pass me a beer.
Zars, 2012, Science 335(6074): 1309--1310 [FBrf0217927]

Male sexual behaviour and ethanol consumption from an evolutionary perspective: A comment on "Sexual Deprivation Increases Ethanol Intake in Drosophila".
Guevara-Fiore and Endler, 2014, Fly 8(4): 234--236 [FBrf0228948]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Science
    Title
    Science
    Publication Year
    1895-
    ISBN/ISSN
    0036-8075
    Data From Reference
    Alleles (4)
    Genes (5)
    Human Disease Models (1)
    Transgenic Constructs (3)