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Citation
Ge, W., Chen, Y.W., Weng, R., Lim, S.F., Buescher, M., Zhang, R., Cohen, S.M. (2012). Overlapping functions of microRNAs in control of apoptosis during Drosophila embryogenesis.  Cell Death Differ. 19(5): 839--846.
FlyBase ID
FBrf0217965
Publication Type
Research paper
Abstract

Regulation of apoptosis is crucial for tissue homeostasis under normal development and environmental stress. In Drosophila, cell death occurs in different developmental processes including embryogenesis. Here, we report that two members of the miR-2 seed family of microRNAs, miR-6 and miR-11, function together to limit the level of apoptosis during Drosophila embryonic development. Mutants lacking both miR-6 and miR-11 show embryonic lethality and defects in the central nervous system (CNS). We provide evidence that miR-6/11 functions through regulation of the proapoptotic genes, reaper (rpr), head involution defective (hid), grim and sickle (skl). Upregulation of these proapoptotic genes is responsible for the elevated apoptosis and the CNS defects in the mutants. These findings demonstrate that the activity of the proapoptotic genes is kept in check by miR-6/11 to ensure normal development.

PubMed ID
PubMed Central ID
PMC3321623 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell Death Differ.
    Title
    Cell Death and Differentiation
    Publication Year
    1994-
    ISBN/ISSN
    1350-9047
    Data From Reference
    Aberrations (5)
    Alleles (7)
    Genes (10)
    Insertions (3)
    Experimental Tools (2)
    Transgenic Constructs (1)