Open Close
Reference
Citation
Marek, L.R., Kagan, J.C. (2012). Phosphoinositide Binding by the Toll Adaptor dMyD88 Controls Antibacterial Responses in Drosophila.  Immunity 36(4): 612--622.
FlyBase ID
FBrf0218122
Publication Type
Research paper
Abstract

The cell biological principles that govern innate immune responses in Drosophila are unknown. Here, we report that Toll signaling in flies was dictated by the subcellular localization of the adaptor protein dMyD88. dMyD88 was located at the plasma membrane by a process dependent on a C-terminal phosphoinositide-binding domain. In vivo analysis revealed that lipid binding by dMyD88 was necessary for its antimicrobial and developmental functions as well as for the recruitment of the downstream cytosolic adaptor Tube to the cell surface. These data are reminiscent of the interactions between the mammalian Toll adaptors MyD88 and TIRAP with one major exception. In the mammalian system, MyD88 is the cytosolic adaptor that depends on the phosphoinositide-binding protein TIRAP for its recruitment to the cell surface. We therefore propose that dMyD88 is the functional homolog of TIRAP and that both proteins function as sorting adaptors to recruit downstream signaling adaptors to activated receptors.

PubMed ID
PubMed Central ID
PMC3354765 (PMC) (EuropePMC)
Related Publication(s)
Note

Toll Signaling in Flies and Mammals: Two Sorts of MyD88.
Goto and Imler, 2012, Immunity 36(4): 555--557 [FBrf0218137]

Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Immunity
    Title
    Immunity
    Publication Year
    1994-
    ISBN/ISSN
    1074-7613
    Data From Reference
    Alleles (6)
    Gene Groups (1)
    Genes (6)
    Natural transposons (1)
    Experimental Tools (2)
    Transgenic Constructs (5)