Open Close
Reference
Citation
Toledano, H., D'Alterio, C., Czech, B., Levine, E., Jones, D.L. (2012). The let-7-Imp axis regulates ageing of the Drosophila testis stem-cell niche.  Nature 485(7400): 605--610.
FlyBase ID
FBrf0218483
Publication Type
Research paper
Abstract

Adult stem cells support tissue homeostasis and repair throughout the life of an individual. During ageing, numerous intrinsic and extrinsic changes occur that result in altered stem-cell behaviour and reduced tissue maintenance and regeneration. In the Drosophila testis, ageing results in a marked decrease in the self-renewal factor Unpaired (Upd), leading to a concomitant loss of germline stem cells. Here we demonstrate that IGF-II messenger RNA binding protein (Imp) counteracts endogenous small interfering RNAs to stabilize upd (also known as os) RNA. However, similar to upd, Imp expression decreases in the hub cells of older males, which is due to the targeting of Imp by the heterochronic microRNA let-7. In the absence of Imp, upd mRNA therefore becomes unprotected and susceptible to degradation. Understanding the mechanistic basis for ageing-related changes in stem-cell behaviour will lead to the development of strategies to treat age-onset diseases and facilitate stem-cell-based therapies in older individuals.

PubMed ID
PubMed Central ID
PMC4829122 (PMC) (EuropePMC)
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nature
    Title
    Nature
    Publication Year
    1869-
    ISBN/ISSN
    0028-0836
    Data From Reference
    Aberrations (2)
    Alleles (18)
    Gene Groups (1)
    Genes (9)
    Physical Interactions (4)
    Cell Lines (1)
    Natural transposons (2)
    Insertions (5)
    Experimental Tools (2)
    Transgenic Constructs (7)