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Citation
Malone, J.H., Cho, D.Y., Mattiuzzo, N.R., Artieri, C.G., Jiang, L., Dale, R.K., Smith, H.E., McDaniel, J., Munro, S., Salit, M., Andrews, J., Przytycka, T.M., Oliver, B. (2012). Mediation of Drosophila autosomal dosage effects and compensation by network interactions.  Genome Biol. 13(4): r28.
FlyBase ID
FBrf0219684
Publication Type
Research paper
Abstract

Gene dosage change is a mild perturbation that is a valuable tool for pathway reconstruction in Drosophila. While it is often assumed that reducing gene dose by half leads to two-fold less expression, there is partial autosomal dosage compensation in Drosophila, which may be mediated by feedback or buffering in expression networks.We profiled expression in engineered flies where gene dose was reduced from two to one. While expression of most one-dose genes was reduced, the gene-specific dose responses were heterogeneous. Expression of two-dose genes that are first-degree neighbors of one-dose genes in novel network models also changed, and the directionality of change depended on the response of one-dose genes.Our data indicate that expression perturbation propagates in network space. Autosomal compensation, or the lack thereof, is a gene-specific response, largely mediated by interactions with the rest of the transcriptome.

PubMed ID
PubMed Central ID
PMC3446302 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genome Biol.
    Title
    Genome Biology
    Publication Year
    2000-
    ISBN/ISSN
    1474-7596 1474-760X
    Data From Reference