FB2025_01 , released February 20, 2025
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Citation
Hill, R.J., Billas, I.M., Bonneton, F., Graham, L.D., Lawrence, M.C. (2013). Ecdysone receptors: from the ashburner model to structural biology.  A. Rev. Ent. 58(): 251--271.
FlyBase ID
FBrf0220517
Publication Type
Review
Abstract
In 1974, Ashburner and colleagues postulated a model to explain the control of the puffing sequence on Drosophila polytene chromosomes initiated by the molting hormone 20-hydroxyecdysone. This model inspired a generation of molecular biologists to clone and characterize elements of the model, thereby providing insights into the control of gene networks by steroids, diatomic gases, and other small molecules. It led to the first cloning of the EcR subunit of the heterodimeric EcR-USP ecdysone receptor. X-ray diffraction studies of the ligand-binding domain of the receptor are elucidating the specificity of receptor-ecdysteroid interactions, the selectivity of some environmentally friendly insecticides, the evolution of the EcR-USP heterodimer, and indeed Ashburner's classical biochemical evidence for the central role of the ecdysone receptor in his model.
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Compendium
    Abbreviation
    A. Rev. Ent.
    Title
    Annual Review of Entomology
    Publication Year
    1957-
    ISBN/ISSN
    0066-4170
    Data From Reference
    Genes (6)