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Citation
Merkling, S.H., van Rij, R.P. (2013). Beyond RNAi: Antiviral defense strategies in Drosophila and mosquito.  J. Insect Physiol. 59(2): 159--170.
FlyBase ID
FBrf0220761
Publication Type
Review
Abstract

Virus transmission and spread by arthropods is a major economic and public health concern. The ongoing dissemination of arthropod-borne viruses by blood-feeding insects is an important incentive to study antiviral immunity in these animals. RNA interference is a major mechanism for antiviral defense in insects, including the fruit fly Drosophila melanogaster and several vector mosquitoes. However, recent data suggest that the evolutionary conserved Toll, Imd and Jak-Stat signaling pathways also contribute to antiviral immunity. Moreover, symbionts, such as the intracellular bacterium Wolbachia and the gut microflora, influence the course of virus infection in insects. These results add an additional level of complexity to antiviral immunity, but also provide novel opportunities to control the spread of arboviruses. In this review, we provide an overview of the current knowledge and recent developments in antiviral immunity in Dipteran insects, with a focus on non-RNAi mediated inducible responses.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    J. Insect Physiol.
    Title
    Journal of Insect Physiology
    Publication Year
    1957-
    ISBN/ISSN
    0022-1910 1879-1611
    Data From Reference