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Buchon, N., Osman, D., David, F.P., Yu Fang, H., Boquete, J.P., Deplancke, B., Lemaitre, B. (2013). Morphological and molecular characterization of adult midgut compartmentalization in Drosophila.  Cell Rep. 3(5): 1725--1738.
FlyBase ID
FBrf0221749
Publication Type
Research paper
Abstract

Although the gut is a central organ of Eumetazoans and is essential for organismal health, our understanding of its morphological and molecular determinants remains rudimentary. Here, we provide a comprehensive atlas of Drosophila adult midgut. Specifically, we uncover a fine-grained regional organization consisting of 14 subregions with distinct morphological, histological, and genetic properties. We also show that Drosophila intestinal regionalization is defined after adult emergence, remains stable throughout life, and reestablishes following acute tissue damage. Additionally, we show that this midgut compartmentalization is achieved through the interplay between pan-midgut and regionalized transcription factors, in concert with spatial activities of morphogens. Interestingly, disruption of the midgut compartmentalization leads to a loss of intestinal homeostasis characterized by an increase in stem cell proliferation and aberrant immune responses. Our integrative analysis of Drosophila midgut compartmentalization provides insights into the conserved mechanisms underlying intestinal regionalization in metazoans.

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Obtained with permission from Cell Press.
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Related Publication(s)
Note

Regional Specificity in the Drosophila Midgut: Setting Boundaries with Stem Cells.
O'Brien, 2013, Cell Stem Cell 13(4): 375--376 [FBrf0222909]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell Rep.
    Title
    Cell reports
    ISBN/ISSN
    2211-1247
    Data From Reference