Open Close
Reference
Citation
Sánchez-Higueras, C., Sotillos, S., Castelli-Gair Hombría, J. (2014). Common origin of insect trachea and endocrine organs from a segmentally repeated precursor.  Curr. Biol. 24(1): 76--81.
FlyBase ID
FBrf0223768
Publication Type
Research paper
Abstract

Segmented organisms have serially repeated structures [1] that become specialized in some segments [2]. We show here that the Drosophila corpora allata, prothoracic glands, and trachea have a homologous origin and can convert into each other. The tracheal epithelial tubes develop from ten trunk placodes [3, 4], and homologous ectodermal cells in the maxilla and labium form the corpora allata and the prothoracic glands. The early endocrine and trachea gene networks are similar, with STAT and Hox genes inducing their activation. The initial invagination of the trachea and the endocrine primordia is identical, but activation of Snail in the glands induces an epithelial-mesenchymal transition (EMT), after which the corpora allata and prothoracic gland primordia coalesce and migrate dorsally, joining the corpora cardiaca to form the ring gland. We propose that the arthropod ectodermal endocrine glands and respiratory organs arose through an extreme process of divergent evolution from a metameric repeated structure.

Graphical Abstract
Obtained with permission from Cell Press.
PubMed ID
PubMed Central ID
Related Publication(s)
Note

Development: a deep breath for endocrine organ evolution.
Grillo et al., 2014, Curr. Biol. 24(1): R38--R40 [FBrf0223787]

Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Curr. Biol.
    Title
    Current Biology
    Publication Year
    1991-
    ISBN/ISSN
    0960-9822
    Data From Reference