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Salzmann, V., Inaba, M., Cheng, J., Yamashita, Y.M. (2013). Lineage tracing quantification reveals symmetric stem cell division in Drosophila male germline stem cells.  Cell. Mol. Bioeng. 6(4): 441--448.
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Research paper

In the homeostatic state, adult stem cells divide either symmetrically to increase the stem cell number to compensate stem cell loss, or asymmetrically to maintain the population while producing differentiated cells. We have investigated the mode of stem cell division in the testes of Drosophila melanogaster by lineage tracing and confirm the presence of symmetric stem cell division in this system. We found that the rate of symmetric division is limited to 1-2% of total germline stem cell (GSC) divisions, but it increases with expression of a cell adhesion molecule, E-cadherin, or a regulator of the actin cytoskeleton, Moesin, which may modulate adhesiveness of germ cells to the stem cell niche. Our results indicate that the decision regarding asymmetric vs. symmetric division is a dynamically regulated process that contributes to tissue homeostasis, responding to the needs of the tissue.

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PMC3899098 (PMC) (EuropePMC)
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    Publication Type
    Cell. Mol. Bioeng.
    Cellular and molecular bioengineering
    1865-5025 1865-5033
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    Alleles (5)
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