Open Close
Reference
Citation
Shukla, A.K., Pragya, P., Chaouhan, H.S., Patel, D.K., Abdin, M.Z., Kar Chowdhuri, D. (2014). A mutation in Drosophila methuselah resists paraquat induced Parkinson-like phenotypes.  Neurobiol. Aging 35(10): 2419.e1--2419.e16.
FlyBase ID
FBrf0225541
Publication Type
Research paper
Abstract

Parkinson's disease (PD) is a prevalent and devastating neurodegenerative disorder having limited cure options and strong association with the loss of dopaminergic neurons in the substantia nigra region of the mid brain. Etiology of PD includes both genetic and environmental factors. Paraquat (PQ), a widely used herbicide, is known to be associated with pathogenesis of PD. We report that a mutation in Drosophila methuselah (mth(1)), which is associated with aging, has a role in preventing dopaminergic neuronal cell death in PQ-exposed organism. Exposed mth(1) flies exhibit significant resistance against PQ-induced Parkinson's phenotypes and behavior in terms of oxidative stress, dopaminergic neuronal degeneration, locomotor performance, dopamine content, phosphorylated JNK, pFOXO, Hid, and cleaved caspase-3 levels. Conversely, over-expression of mth in dopaminergic neurons makes the exposed organism more vulnerable to oxidative stress, neuronal cell death, and behavioral deficit. The study suggests that lesser activation of JNK-mediated apoptosis in dopaminergic neurons of exposed mth(1) flies protects the organism from PQ-induced damage, which may be causally linked to a common mechanism for PQ-induced neurodegeneration.

PubMed ID
PubMed Central ID
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neurobiol. Aging
    Title
    Neurobiology of Aging
    Publication Year
    1980-
    ISBN/ISSN
    0197-4580
    Data From Reference
    Alleles (6)
    Genes (4)
    Human Disease Models (1)
    Transgenic Constructs (5)