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Citation
Spéder, P., Brand, A.H. (2014). Gap junction proteins in the blood-brain barrier control nutrient-dependent reactivation of Drosophila neural stem cells.  Dev. Cell 30(3): 309--321.
FlyBase ID
FBrf0225896
Publication Type
Research paper
Abstract

Neural stem cells in the adult brain exist primarily in a quiescent state but are reactivated in response to changing physiological conditions. How do stem cells sense and respond to metabolic changes? In the Drosophila CNS, quiescent neural stem cells are reactivated synchronously in response to a nutritional stimulus. Feeding triggers insulin production by blood-brain barrier glial cells, activating the insulin/insulin-like growth factor pathway in underlying neural stem cells and stimulating their growth and proliferation. Here we show that gap junctions in the blood-brain barrier glia mediate the influence of metabolic changes on stem cell behavior, enabling glia to respond to nutritional signals and reactivate quiescent stem cells. We propose that gap junctions in the blood-brain barrier are required to translate metabolic signals into synchronized calcium pulses and insulin secretion.

Graphical Abstract
Obtained with permission from Cell Press.
PubMed ID
PubMed Central ID
PMC4139190 (PMC) (EuropePMC)
Related Publication(s)
Note

Closing the gap between glia and neuroblast proliferation.
Limmer and Klämbt, 2014, Dev. Cell 30(3): 249--250 [FBrf0226501]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Cell
    Title
    Developmental Cell
    Publication Year
    2001-
    ISBN/ISSN
    1534-5807 1878-1551
    Data From Reference
    Aberrations (1)
    Alleles (62)
    Genes (20)
    Natural transposons (1)
    Insertions (22)
    Experimental Tools (4)
    Transgenic Constructs (39)
    Transcripts (15)