Open Close
Ito, S., Ueda, T., Ueno, A., Nakagawa, H., Taniguchi, H., Kayukawa, N., Miki, T. (2014). A genetic screen in Drosophila for regulators of human prostate cancer progression.  Biochem. Biophys. Res. Commun. 451(4): 548--555.
FlyBase ID
Publication Type
Research paper

To uncover the mechanism by which human prostate cancer progresses, we performed a genetic screen for regulators of human prostate cancer progression using the Drosophila accessory gland, a functional homolog of the mammalian prostate. Cell growth and migration of secondary cells in the adult male accessory gland were found to be regulated by paired, N-cadherin, and E-cadherin, which are Drosophila homologues of regulators of human prostate cancer progression. Using this screening system, we also identified three genes that promoted growth and migration of secondary cells in the accessory gland. The human homologues of these candidate genes - MRGBP, CNPY2, and MEP1A - were found to be expressed in human prostate cancer model cells and to promote replication and invasiveness in these cells. These findings suggest that the development of the Drosophila accessory gland and human prostate cancer cell growth and invasion are partly regulated through a common mechanism. The screening system using the Drosophila accessory gland can be a useful tool for uncovering the mechanisms of human prostate cancer progression.

PubMed ID
PubMed Central ID
Associated Information
Associated Files
Other Information
Secondary IDs
    Language of Publication
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Biochem. Biophys. Res. Commun.
    Biochemical and Biophysical Research Communications
    Publication Year
    Data From Reference
    Alleles (30)
    Genes (31)
    Human Disease Models (6)
    Insertions (1)
    Transgenic Constructs (29)
    Transcripts (1)