Open Close
Reference
Citation
Ma, Q., Wawersik, M., Matunis, E.L. (2014). The Jak-STAT Target Chinmo Prevents Sex Transformation of Adult Stem Cells in the Drosophila Testis Niche.  Dev. Cell 31(4): 474--486.
FlyBase ID
FBrf0226905
Publication Type
Research paper
Abstract

Local signals maintain adult stem cells in many tissues. Whether the sexual identity of adult stem cells must also be maintained was not known. In the adult Drosophila testis niche, local Jak-STAT signaling promotes somatic cyst stem cell (CySC) renewal through several effectors, including the putative transcription factor Chronologically inappropriate morphogenesis (Chinmo). Here, we find that Chinmo also prevents feminization of CySCs. Chinmo promotes expression of the canonical male sex determination factor DoublesexM (Dsx(M)) within CySCs and their progeny, and ectopic expression of DsxM in the CySC lineage partially rescues the chinmo sex transformation phenotype, placing Chinmo upstream of Dsx(M). The Dsx homolog DMRT1 prevents the male-to-female conversion of differentiated somatic cells in the adult mammalian testis, but its regulation is not well understood. Our work indicates that sex maintenance occurs in adult somatic stem cells and that this highly conserved process is governed by effectors of niche signals. PAPERCLIP:

PubMed ID
PubMed Central ID
PMC4254588 (PMC) (EuropePMC)
Related Publication(s)
Note

chinmo Mutant Fly Testis Stem Cells Switching Sex Farewell to Maleness.
Zarkower, 2014, Dev. Cell 31(4): 385--387 [FBrf0226997]

Stem cells: A case of mistaken identity.
Koch, 2015, Nat. Rev. Genet. 16(1): 4 [FBrf0228079]

Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Cell
    Title
    Developmental Cell
    Publication Year
    2001-
    ISBN/ISSN
    1534-5807 1878-1551
    Data From Reference