Open Close
Reference
Citation
Owald, D., Felsenberg, J., Talbot, C.B., Das, G., Perisse, E., Huetteroth, W., Waddell, S. (2015). Activity of defined mushroom body output neurons underlies learned olfactory behavior in Drosophila.  Neuron 86(2): 417--427.
FlyBase ID
FBrf0228212
Publication Type
Research paper
Abstract

During olfactory learning in fruit flies, dopaminergic neurons assign value to odor representations in the mushroom body Kenyon cells. Here we identify a class of downstream glutamatergic mushroom body output neurons (MBONs) called M4/6, or MBON-β2β'2a, MBON-β'2mp, and MBON-γ5β'2a, whose dendritic fields overlap with dopaminergic neuron projections in the tips of the β, β', and γ lobes. This anatomy and their odor tuning suggests that M4/6 neurons pool odor-driven Kenyon cell synaptic outputs. Like that of mushroom body neurons, M4/6 output is required for expression of appetitive and aversive memory performance. Moreover, appetitive and aversive olfactory conditioning bidirectionally alters the relative odor-drive of M4β' neurons (MBON-β'2mp). Direct block of M4/6 neurons in naive flies mimics appetitive conditioning, being sufficient to convert odor-driven avoidance into approach, while optogenetically activating these neurons induces avoidance behavior. We therefore propose that drive to the M4/6 neurons reflects odor-directed behavioral choice.

PubMed ID
PubMed Central ID
PMC4416108 (PMC) (EuropePMC)
Related Publication(s)
Note

Learning: the good, the bad, and the fly.
Hige and Turner, 2015, Neuron 86(2): 343--345 [FBrf0228259]

Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neuron
    Title
    Neuron
    Publication Year
    1988-
    ISBN/ISSN
    0896-6273
    Data From Reference