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Citation
Tataroglu, O., Emery, P. (2015). The molecular ticks of the Drosophila circadian clock.  Curr. Opin. Insect Sci. 7(): 51--57.
FlyBase ID
FBrf0228783
Publication Type
Review
Abstract

Drosophila is a powerful model to understand the mechanisms underlying circadian rhythms. The Drosophila molecular clock is comprised of transcriptional feedback loops. The expressions of the critical transcriptional activator CLK and its repressors PER and TIM are under tight transcriptional control. However, posttranslational modification of these proteins and regulation of their stability are critical to their function and to the generation of 24-hr period rhythms. We review here recent progress made in our understanding of PER, TIM and CLK posttranslational control. We also review recent studies that are uncovering the importance of novel regulatory mechanisms that affect mRNA stability and translation of circadian pacemaker proteins and their output.

PubMed ID
PubMed Central ID
PMC4480617 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Curr. Opin. Insect Sci.
    Title
    Current opinion in insect science
    ISBN/ISSN
    2214-5753 2214-5745
    Data From Reference