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Citation
Dus, M., Lai, J.S., Gunapala, K.M., Min, S., Tayler, T.D., Hergarden, A.C., Geraud, E., Joseph, C.M., Suh, G.S. (2015). Nutrient Sensor in the Brain Directs the Action of the Brain-Gut Axis in Drosophila.  Neuron 87(1): 139--151.
FlyBase ID
FBrf0228903
Publication Type
Research paper
Abstract

Animals can detect and consume nutritive sugars without the influence of taste. However, the identity of the taste-independent nutrient sensor and the mechanism by which animals respond to the nutritional value of sugar are unclear. Here, we report that six neurosecretory cells in the Drosophila brain that produce Diuretic hormone 44 (Dh44), a homolog of the mammalian corticotropin-releasing hormone (CRH), were specifically activated by nutritive sugars. Flies in which the activity of these neurons or the expression of Dh44 was disrupted failed to select nutritive sugars. Manipulation of the function of Dh44 receptors had a similar effect. Notably, artificial activation of Dh44 receptor-1 neurons resulted in proboscis extensions and frequent episodes of excretion. Conversely, reduced Dh44 activity led to decreased excretion. Together, these actions facilitate ingestion and digestion of nutritive foods. We propose that the Dh44 system directs the detection and consumption of nutritive sugars through a positive feedback loop.

PubMed ID
PubMed Central ID
PMC4697866 (PMC) (EuropePMC)
Related Publication(s)
Note

Neuroendocrinology: More nutritious than delicious.
Bray, 2015, Nat. Rev. Neurosci. 16(8): 442--443 [FBrf0229743]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neuron
    Title
    Neuron
    Publication Year
    1988-
    ISBN/ISSN
    0896-6273
    Data From Reference