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Citation
Crosby, M.A., Gramates, L.S., Dos Santos, G., Matthews, B.B., St Pierre, S.E., Zhou, P., Schroeder, A.J., Falls, K., Emmert, D.B., Russo, S.M., Gelbart, W.M., FlyBase Consortium, (2015). Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.  G3 (Bethesda) 5(8): 1737--1749.
FlyBase ID
FBrf0229217
Publication Type
Research paper
Abstract

In the context of the FlyBase annotated gene models in Drosophila melanogaster, we describe the many exceptional cases we have curated from the literature or identified in the course of FlyBase analysis. These range from atypical but common examples such as dicistronic and polycistronic transcripts, noncanonical splices, trans-spliced transcripts, noncanonical translation starts, and stop-codon readthroughs, to single exceptional cases such as ribosomal frameshifting and HAC1-type intron processing. In FlyBase, exceptional genes and transcripts are flagged with Sequence Ontology terms and/or standardized comments. Because some of the rule-benders create problems for handlers of high-throughput data, we discuss plans for flagging these cases in bulk data downloads.

PubMed ID
PubMed Central ID
PMC4528330 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    G3 (Bethesda)
    Title
    G3 : genes - genomes - genetics
    ISBN/ISSN
    2160-1836
    Data From Reference